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New Lipoxygenase Inhibitor

IN 00100 Linoleyl hydroxamic acid [octa-9,12-dienehydroxamic acid (z,z-)]

MP : 45° C MW: 295.4

Purity: ³ 99% Stability: ³ 1 year at 0° C under argon

• White powder

• Air and light sensitive

• Soluble in alcohols, ethers, hydrocarbons. Not soluble in water

BIOLOGICAL PROPERTIES:

• A suicidal inhibitor of soybean 15-LO; IC₅₀ = 2X10^-7 M [1]

• An inhibitor of potato tuber 5-LO; IC₅₀ < 1 X 10^-6 M [2]

• An inhibitor of leukotriene biosynthesis [3]

octa-9,12-dienehydroxamic acid (z,z)-

PRICE:

REFERENCES:

1. I.A. Butovich, V.P. Bridnya, V.P. Kukhar, Linoleyl hyrdoxamic acid-a suicidal inhibitor of lipoxygenase, Biokhimiya, 1990, 55 (7): 1216-1221.
2. I.A. Butovich, et al., Linoleyl hyrdoxamic acid as inhibitor of 5-lipoxygenase, Biokhimiya, 1994, 59 (6): 808-813.
3. A.A. Moibenko et al., The mechanisms of the changes in coronary vascular resistance in anaphylactic shock, Fiziol. Zh. Im. I.M. Sechenova, 1994 Feb, 80 (2): 77-82.

CALL (518)-605-8808 or FAX: (206)-337-1074 FOR ORDERING